by M Potts and D W Evans
J. Med. Ethics 2005;31;406-409


The "standard position" on organ donation is that the donor must be dead in order for vital organs to be removed, a position with which we agree. Recently, Robert Truog and Walter Robinson have argued that (1) brain death is not death, and (2) even though "brain dead" patients are not dead, it is morally acceptable to remove vital organs from those patients. We accept and defend their claim that brain death is not death, and we argue against both the US "whole brain" criterion and the UK "brain stem" criterion. Then we answer their arguments in favour of removing vital organs from "brain dead" and other classes of comatose patients. We dispute their claim that the removal of vital organs is morally equivalent to "letting nature take its course", arguing that, unlike "allowing to die", it is the removal of vital organs that kills the patient, not his or her disease or injury. Then, we argue that removing vital organs from living patients is immoral and contrary to the nature of medical practice. Finally, we offer practical suggestions for changing public policy on organ transplantation.

In a recent article, Robert Truog and Walter Robinson note:

"The practice of organ transplantation has been wedded to the concept of brain death for most of its history"[1]. The link "is the dead donor rule, which requires that patients be declared dead before the removal" of unpaired vital organs – for example, heart, liver, or two paired vital organs (such as kidneys)[1]. Movement toward changing the criteria of death from cardiopulmonary to brain based criteria was already taking place at Cape Town in 1967, due to pressure for a viable heart for transplantation[2-8]. The consequence of the recipients᾿ short survival was, as the BMJs deputy editor put it, "a euphoric, uncontrolled epidemic of heart transplantation around the world"[9]. This, together with demand for other organs which required that they be perfused until their removal, necessitated "the production of a set of legal and philosophical justifications"[2] for procedures that would otherwise be seen as assault. In the United States, the Harvard ad hoc committee for the determination of brain death proposed, in 1968, a new set of criteria for death based on "irreversible coma" with "no discernible central nervous system activity"[10] (italics in original). This report paved the way for the 1981 Presidents Commission report[11], which supported "whole brain" criteria for death – criteria enshrined in the Uniform Determination of Death Act (UDDA), which is now law in almost all US states and the basis of "accepted practice" in many parts of the world. Despite attacks upon the coherence and empirical adequacy of such whole brain criteria[12,13], the Presidents Commission report and UDDA remained the "bible" for diagnosis of death in the US. In the last ten years, fresh attacks on brain death criteria[14-17] have eroded their perceived invulnerability. Their conceptual and empirical foundations are collapsing. Calixto Machado and Alan Shewmon, in a newly published anthology[18], note that there are still worldwide controversies over the very concept of human death and the putative neurological grounds for diagnosing it (whole brain, brain stem, and higher brain formulations of death). There are also disagreements over the diagnostic criteria of brain death, whether clinical alone, or clinical plus ancillary tests. Moreover, a group of scholars who were strong defenders of brain based criteria of death are now favouring a circulatory/respiratory view. Hence, the debates on human death are far from concluded.

This trend is reflected in the paper by Truog and Robinson, who note that the concept of brain death "fails to correspond to any coherent biological or philosophical understanding of death"[1]. We believe this claim well founded. There were never sound empirical grounds for criteria of death based on the loss of testable brain function while the body remains alive. One difficulty is the near impossibility of diagnosing – with the necessary certainty – the "irreversible cessation of all functions of the entire brain, including the brain stem"[11] while the rest of the body remains alive. The Harvard tests – essentially of brain stem mediated reflexes and ventilator dependence in patients whose coma appeared irremediable – clearly lacked the power to make that diagnosis. The many protocols now in use worldwide fail similarly. Indeed, their very number [19,20] proclaims the fact that the syndromes they diagnose cannot be one and the same true entity. And prominent among the variations is the apnoea test, which may lead to the misdiagnosis of respiratory centre failure if inadequately stimulating and, if stringently applied, may itself be the cause of death[21].

Truog and Robinson acknowledge that many patients currently diagnosed "brain dead" do not, in fact, meet the American legal requirements governing that practice. They note that many retain demonstrable brain function – and that this knowledge, which should be a challenge to those certifying death on the basis that there is no such activity – is set aside as not "significant"[1]. That dismissal is similar to the stance assumed by those who supported the brain stem death criteria which became UK policy in 1979. They promulgated a set of prognostic criteria, first published in 1976, with a directive that they were to be used thenceforth as criteria for the diagnosis of death[22]. This conceptual confusion was compounded by the assumption that permanent incapacity for consciousness could be safely assumed when some brain stem mediated reflexes were absent in comatose patients whose apnoea appeared permanent. Like the US "whole brain criteria", the UK criteria – held to define death conceptualised as permanent loss of the capacity for consciousness and the capacity to breathe spontaneously[23] – did not require the electroencephalogram (EEG) as a test for continuing life in the brain. If recorded, continuing EEG activity was to be disregarded – along with other evidence of persisting brain function – as lacking "significance". It remains unclear, however, on what grounds such activity is disregarded, bearing in mind the present very limited understanding of brain physiology.

Although the term "brain death" is supposed to have gone out of use in the UK[22], comatose, ventilator/dependent patients are still being certified "dead" for transplant purposes using similar tests but on the basis of some idiosyncratic concept that remains far from clear. In the US, criticisms of brain death criteria have remained a matter of academic debate and have not filtered down to the level of public policy. The UDDA and the "dead donor rule" still govern transplantation practice. Truog and Robinson, like others before them[24-25], propose the abandonment of all obfuscation where requests for transplantable organs are concerned. They accept that "brain dead" individuals are alive. The issue then becomes: "Given that brain dead individuals are not dead, is it morally acceptable to remove their organs for transplantation?"

Truog and Robinson answer "yes", and "propose that the ethics of organ donation be based on the ethical principles of non-maleficence and respect for persons rather than on brain death and the dead donor rule"[1]. They "propose that sometimes the harm of dying is sufficiently small that patients should be allowed to voluntarily accept that harm if it makes organ donation possible"[1]. They are not in favour of just anyone donating their vital organs. Rather, they accept the idea that there must be some "threshold" state above which organ donation would not be permitted[1]. It would be permissible to use as donors at least two classes of patients who had given prior consent: the "permanently unconscious" and the "imminently dying"[1]. Ultimately, it would be up to "society" to determine the minimal threshold of lively existence below which donation would be permitted[1]. They suggest that organ donation from the "permanently unconscious" be limited to patients declared "brain dead" by current standards, because of uncertainty about the "capacity for consciousness" in patients in a persistent vegetative state or in anencephalic newborns[1]. The "imminently dying" group should initially be limited "to those patients completely dependent on life support, in whom death would be expected within minutes of withdrawal of that support, and in whom no treatment alternatives are available or desired". This would include "patients with cervical quadriplegia who desired withdrawal of mechanical ventilation or patients on cardiac support devices who refused continuation of that support or other treatment alternatives"[1]. Such patients would normally grant permission for organ removal themselves, "removing any concerns about the legitimacy of surrogate decision making in cases like this"[1]. Practically, these limitations imply that there is "a large gap between the category of patients permitted to have withdrawal of life support and the category of patients permitted to donate organs"[1]. The former group will be the larger, because more categories of patients would be allowed to refuse life prolonging treatment than those allowed to donate their organs.

For Truog and Robinson, the case for taking organs from still living donors depends upon "shifting the key ethical question from Is the patient dead? to Are the harms of removing life-sustaining organs sufficiently small that patients or surrogates should be allowed to consent to donation?"[1]. Their answer to the second question is "yes", at least for some classes of patients. These authors believe that the current practice of harvesting organs from donors "who meet brain death criteria... [is] clearly ethical – not because the patients are dead, but rather because they have been rendered permanently unconscious from an overwhelming brain injury"[1]. As far as the larger class of patients eligible for "non-heart beating organ donation" is concerned, a group that includes individuals who do not meet brain death criteria, they suggest that rather than removing their organs after a set period of time following cardiac arrest, it would be better to remove their organs before ischaemic cardiac arrest. This not only overcomes the problem of "orchestrated death in these protocols", it also "optimise[s] both the number and the viability of the organs obtained"[1].

To answer the charge that vital organ removal kills the living patient, Truog and Robinson argue that there is a parallel between organ procurement and ventilator withdrawal: "In both ventilator withdrawal and organ procurement, the physician acts, and this act is the most proximate cause of the patient᾿s death. In both cases, the physician is not morally responsible for the patient᾿s death – the morally relevant cause of death is the patient᾿s disease. In both cases, the physician is acting with the patient᾿s consent in ways that respect the wishes of the patient and that are in the pursuit of morally worthwhile ends"[1].

Once we recognise that the dead donor rule is not morally necessary for organ procurement, the "concept of brain death will then disappear from textbooks, illustrating the degree to which the concept was never more than a social construction, developed to meet the needs of the transplantation enterprise during a crucial phase of its development"[1].

We contend that Truog and Robinson᾿s arguments for the moral acceptability of organ procurement once the dead donor rule is eliminated are unsuccessful, and that the unacceptability of such transplantation should lead to changes in current policy. We believe that removing vital organs from a still living donor is the taking of innocent human life. The argument that such removal is morally no different from "allowing to die" by removing a ventilator is seriously flawed. When a ventilator is removed from an apnoeic comatose patient, it is the disease or injury that causes the loss of the patient᾿s ability to breathe spontaneously. As Margaret Somerville notes: "the withdrawal of life support treatment such as respiratory support involves a situation of multiple causation in which one cause (respiratory failure) is sufficient to cause death; the other cause (turning off the respirator) is not sufficient in the absence of respiratory failure"[26]. The situation is different when vital organs are removed from a patient. Removing a vital organ, such as the heart, directly causes the death of the patient, and is not merely allowing the effects of disease or injury to take their course. It is the organ removal surgery that kills the donor. In addition, withdrawal of life support may be an acceptable omission of burdensome treatment, rather than an act that is more likely to involve an intent to kill the patient. The issue in removing vital organs from brain dead individuals is not, therefore, whether to withdraw burdensome life support from a dying patient but whether such organ removal is a morally acceptable form of killing. Truog and Robinson say it is. As Truog says elsewhere, organ transplantation involves "a form of justified killing" since it does not "harm" "those who are permanently and irreversibly unconscious (patients in a persistent vegetative state or newborns with anencephaly) and those who are imminently and irreversibly dying"[16].

Truog and Robinson᾿s proposals that unpaired vital organs be removed from "brain dead" and other classes of patients can be seen as the endorsement of killing people for their organs. One difficulty with this is that once utilitarian considerations are used to justify killing ventilator/dependent patients who are dying, those same considerations could also be used to justify killing non-ventilator/dependent patients or patients who are not dying.

Another major problem with doctors being involved in killing patients is that such a practice by medical professionals fundamentally distorts the nature of medicine itself.

Edmund Pellegrino and David Thomasma have developed the idea that medicine is primarily a relationship between a sick or injured person needing help and the physician or other health care provider who is trained to provide such help[27]. As such, medicine involves morality as part of its very structure, for there is an imbalance of power and knowledge between the health care provider and the patient (whose vulnerability, when ill, exacerbates this imbalance). This implies a responsibility for the health care provider (1) to have the requisite training and skills and to use those skills competently, and (2) to tell the patient the truth, for trust is necessary for the success of the relationship. It also implies the dictum, "first, do no harm", and the virtues of beneficence (helping the patient in a positive way), and justice.

The fundamental moral problem with killing patients (as opposed to allowing them to die) is that such a practice distorts the very nature of the doctor/patient relationship, since it involves a dangerous use of medical power. The doctor᾿s specialised training gives him (or her) power over his (or her) patient in an intimate way. Using such training to kill subverts its purpose and can easily be used to justify killing other groups of patients on utilitarian grounds. Killing a patient by removing his organs is not legitimate even if he (or his family) requests it. Patient autonomy is not an absolute value that trumps all other values. No decision about life or death matters is ultimately "private", for human beings are by nature social creatures, who live in a web of relationships with other people. Decisions about life and death affect family members, friends, and medical staff. Since the latter are directly involved in removing organs from a donor, the patient᾿s signing of an organ donor form is not a "private decision". Doctors are morally obliged to refuse requests that involve illegitimate exercise of medical power. Requests (oral or written) do not automatically imply an obligation to comply with them. Even if an individual is "brain dead", killing him for the good of others cannot be justified. Crossing that line is dangerous for patients, who are some of the weakest members of society and dependent upon its protection.

If, as we have argued, it is morally wrong to kill patients for their organs, what difference does this make for public policy? If it were generally recognised that "brain dead" patients are alive, would the medical community and general public support a ban on the procurement of organs for transplant from them? Or would they take a position similar to that of Truog and Robinson, holding that even if organ donors are alive, the loss of their lives does such little harm that removing their organs is morally acceptable? There might, perhaps, be support from some for the Truog and Robinson proposal to extend the pool of organ donors beyond those who are "brain dead". Others, however, might be deeply disturbed that living patients are being used as organ donors and would refuse to sign organ donor cards. A key point is that individuals are not able to understand the issues, and therefore cannot give informed consent to organ donation, if they do not receive accurate information about the procedure. They should know that, in current practice, most organs for transplant are taken from "brain dead" individuals[28] who are not dead in the sense that their circulation and respiration have ceased, or that their brains are really and truly dead[22]. They should be aware that the diagnosis of "brain death" is not soundly based or universally accepted[1-14], and that there are serious questions about its constituting the death of the person[29]. The public should also be aware that there remains uncertainty regarding the generation of consciousness in the brain, and that it is not always clear that there is no capacity for consciousness remaining in individuals declared "brain dead"[30].

Much of the information given to the public regarding organ donation and the declaration of death comes through literature in support of people signing organ donor cards. Currently, the statement on organ donor cards asserts that organs may be taken "after my death". We believe that such wording should be changed to reflect the fact that "brain dead" individuals are not dead in the usual understanding of what death is. Explanatory literature accompanying organ donor cards should be frank that a "brain dead" donor᾿s heart is beating during part of the organ removal surgery. There should be open public discussion and debate on the determination of death instead of the current domination of the orthodox "whole brain death" (US) or "brain stem death" (UK) positions. Pluralism on the issue of the determination of death should be publicly acknowledged. Proposals to make organ donation the "default" unless the potential donor says otherwise[31] should be rejected, since such policies are not only open to abuse, but also too easily allow patients who oppose brain death criteria to become organ donors against their wishes. Another difficulty is that such "presumed consent" cannot be valid unless all those eligible to be donors under these policies – that is, the public as a whole – fully understand the organ procurement procedures.

We welcome Truog and Robinson᾿s admission that "brain dead" individuals are not dead and that brain death criteria were developed to allow vital organ donation, rather than being on a firm scientific or philosophical basis. We sharply disagree, however, with their position that it is morally acceptable for this to continue, albeit on some new understanding of what is being done. The general acceptance of the practice since 1968 (in the US) is irrelevant to its moral rightness or wrongness.



Authors᾿ affiliations

D W Evans, Queens College, Cambridge, Cambridge, UK.

M Potts, Philosophy and Religion Department, Methodist College, 5400 Ramsey Street, Fayetteville, NC 28311-1498, USA.

David Evans is a sometime consultant cardiologist to Papworth and Addenbrookes Hospitals, Cambridge, UK. Professor Potts is Chair of the Philosophy and Religion Department and Associate Professor of Philosophy at Methodist College, Fayetteville, NC, USA.




EEG, electroencephalogram; UDDA, uniform determination of death act.




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(Source: J. Med. Ethics 2005;31;406-409 doi:10.1136/jme.2004.010298)

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